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Drug-coated balloon-only strategy for percutaneous coronary intervention of left main coronary artery disease: the importance of proper lesion preparation

《医学前沿（英文）》 2023年 第17卷 第1期   页码 75-84 doi: 10.1007/s11684-022-0950-1

摘要： This retrospective single-center registry study included all consecutive patients who underwent percutaneous coronary intervention (PCI) for a de novo left main coronary artery lesion using drug coated-balloon (DCB)-only strategy between August 2011 and December 2018. To best of our knowledge, no previous studies of DCB-only strategy of treating de novo left main coronary artery disease, exist. The primary endpoint was major adverse cardiovascular events (MACEs) including cardiac death, non-fatal myocardial infarction, and target lesion revascularization (TLR). The cohort was divided into two groups depending on weather the lesion preparation was done according to the international consensus group guidelines. Sixty-six patients (mean age 75±8.6, 72% male), 52% of whom had acute coronary syndrome, underwent left main PCI with the DCB-only strategy. No procedural mortality and no acute closures of the treated left main occurred. At 12 months, MACE and TLR occurred in 24% and 6% of the whole cohort, respectively. If the lesion preparation was done according to the guidelines, the MACE and TLR rates were 21.2% and 1.9%. Left main PCI with the DCB only-strategy is safe leading to acceptable MACE and low TLR rates at one year, if the lesion preparation is done according to the guidelines.

关键词： drug-coated balloon     left main     high bleeding risk     predilatation     calcifield lesion     percutaneous coronary intervention    

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Analysis of the treatment outcomes of esophageal variceal bleeding patients from multiple centers in

WANG Zhiqiang

《医学前沿（英文）》 2008年 第2卷 第2期   页码 171-173 doi: 10.1007/s11684-008-0031-0

摘要： This study aimed to investigate the treatment outcomes of esophageal variceal bleeding (EVB) in China. A total of 1087 cases were collected from 19 hospitals in 16 large and medium sized cities across China between January 1st, 2005 and January 1st, 2006. There were 313 cases (29.0%) of mild (<400 mL), 494 cases (45.8%) of moderate (400–1500 mL) and 272 cases (25.2%) of severe (>1500 mL) bleeding. Successful hemostasis was achieved in 89.8% of cases. Seven hundred and eighty-five cases were treated by medication with a hemostasis rate of 91.8%. Seventy-one cases were treated using a Sengstaken-Blakemore tube with a hemostasis rate of 54.9%. Thirty-seven cases were treated with emergency endoscopic variceal ligation with a hemostasis rate of 83.8%. Seventy-seven cases were treated with endoscopic sclerotherapy with a hemostasis rate of 94.8%. Forty-three cases were treated with emergency surgical operation with a hemostasis rate of 95.3%. Sixty-six cases were treated with combined therapy with a hemostasis rate of 97.0%. There was a significant difference ( < 0.01) in the successful hemostasis rate between different treatments. The overall mortality was 10.1%, among which 6.6% was directly caused by bleeding. The multivariate logistic regression analysis shows that the severity of bleeding, treatment methods, liver dysfunction and activation of hepatitis were predictive factors for successful hemostasis. Most cases of EVB were mild and moderate in severity. The first-line treatment for EVB is medication. Emergency endoscopic intervention has not been widely available yet. The overall management outcome of EVB has been improved.

关键词： significant difference     predictive     medication     first-line treatment     bleeding    

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Identification of surgical patients at high risk of OSAS using the Berlin Questionnaire to detect potentialhigh risk of adverse respiratory events in post anesthesia care unit

null

《医学前沿（英文）》 2018年 第12卷 第2期   页码 189-195 doi: 10.1007/s11684-017-0533-8

摘要：

Obstructive sleep apnea syndrome (OSAS) increases the risk of post-surgery complications. This study uses Berlin Questionnaire (BQ) to identify Chinese adult surgical patients who are at a high risk of OSAS and to determine if the BQ could be used to detect potential high risk of adverse respiratory events in the post anesthesia care unit (PACU). Results indicated that only 11.4% of the patients were considered at a high risk of OSAS. Age and body mass index are the key factors for the risk of OSAS prevalence in China and also gender specific. Furthermore, the incidence of adverse respiratory events in the PACU was higher in patients with high risk of OSAS than others (6.8% vs. 0.9%, <0.001). They also stayed longer than others in the PACU (95±28 min vs. 62±19 min, <0.001). Age, high risk for OSAS, and smoking were independent risk factors for the occurrence of adverse respiratory events in the PACU. The BQ may be adopted as a screening tool for anesthesiologists in China to identify patients who are at high risk of OSAS and determine the potential risk of developing postoperative respiratory complications in the PACU.

关键词： obstructive sleep apnea     Berlin Questionnaire     Chinese surgical patients     adverse respiratory event    

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Effects of microfine aggregate in manufactured sand on bleeding and plastic shrinkage cracking of concrete

Branavan ARULMOLY; Chaminda KONTHESINGHA; Anura NANAYAKKARA

《结构与土木工程前沿（英文）》 2022年 第16卷 第11期   页码 1453-1473 doi: 10.1007/s11709-022-0877-2

摘要： Construction industries have started to utilize manufactured sand (MS) as an effective alternative for river sand in concrete. High-grade parent rocks are crushed to obtain MS, which also produces a considerable amount of microfine aggregate (MFA). The higher percentage of MFA could lead to both positive and negative effects on the performance of cement-based mixes. This research was done to examine the influence of varying MFA levels, specifically 0%, 3%, 6%, 9%, and 12% (by weight) as the partial replacements of MS on bleeding and plastic shrinkage cracking of concrete. In addition to the varying MFA levels, some concrete mixes also included fly ash (FA) and superplasticizer to investigate the effect of free-water content in the mixes. The bleeding test data were taken as on-site measurements, while the cracks from the plastic shrinkage cracking test were evaluated using an image processing technique. The results concluded that the MFA replacements and the effective water-to-cement ratio have a significant effect on the selected concrete properties. With the increasing replacement levels, cumulative bleeding and crack initiation life gradually decreased, while a progressive increase was observed for crack width, crack length, and crack area.

关键词： manufactured sand     fresh concrete     microfines     admixtures     shrinkage     cracking    

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Status of hyperhomocysteinemia in China: results from the China Stroke High-risk Population Screening

《医学前沿（英文）》 2021年 第15卷 第6期   页码 903-912 doi: 10.1007/s11684-021-0871-4

摘要： A nationwide survey was conducted from October 2018 to September 2019 to assess the prevalence of hyperhomocysteinemia (Hhcy) and its influencing factors in China. A standardized questionnaire was used to collect information. Hhcy was defined as the level of serum homocysteine (HCY) ≥15.0 µmol/L. The H-type hypertension (HHYP) was defined as hypertension with an elevated serum HCY (≥15.0 µmol/L). Finally, 110 551 residents ≥40 years of age from 31 provinces in the mainland of China were included. Overall, the median serum HCY level was 10.9 µmol/L (interquartile range 7.9–15.1). A total of 28 633 participants (25.9%) were defined as Hhcy. The Hhcy prevalence ranged from 7.9% in Shanghai to 56.8% in Tianjin. The data showed that serum HCY levels were associated with age, male gender, cigarette smoking, hypertension, diabetes, ethnicity, endurance in exercise (inverse), and fruit and vegetable intake (inverse). In addition, 15 486 participants were defined as HHYP, and the rate was 14.0%. HHYP was an independent predictor of stroke with an adjusted odds ratio of 1.752 (95% CI 1.338–2.105). The geographical distribution pattern of the Hhcy epidemic reflects dynamic differences, and national strategies should be carried out to further improve the care of patients with Hhcy across China.

关键词： homocysteine     hyperhomocysteinemia     H-type hypertension     Chinese    

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Early T-cell precursor leukemia: a subtype of high risk childhood acute lymphoblastic leukemia

null

《医学前沿（英文）》 2012年 第6卷 第4期   页码 416-420 doi: 10.1007/s11684-012-0224-4

摘要：

Acute lymphoblastic leukemia includes T-cell acute lymphoblastic leukemia (T-ALL) and B-cell acute lymphoblastic leukemia (B-ALL). In children, T-ALL usually has a worse prognosis than B-ALL, although childhood T-ALL prognoses have improved remarkably. The varying outcomes among T-ALL cases suggest that an unrecognized biological heterogeneity may contribute to chemo-resistance. Deep exploration of T-lymphocyte development in recent years has found a subgroup of patients with a phenotype that resembles early T-cell precursor, which confers a much poorer prognosis than any other form of T-ALL. This novel subtype of T-ALL was called early T-cell precursor acute lymphoblastic leukemia (ETP-ALL). Flow cytometry data from T-ALL patients enrolled in Shanghai Children’s Medical Center between July 2002 and October 2010 were assessed according to Dr. Campana’s protocol. Among total 89 T-ALL cases, 74 cases had enough immunophenotype data available to differentiate between ETP (CD1a-, CD8-, CD5dim, at least one marker of stem cell or myeloid lineage) and non-ETP. From these 74 subjects, 12 ETP-ALL cases (16.2%) were identified. The event-free survival (EFS) rate at 66.8 months was 11.1%±10.1% for ETP-ALL and 57.6%±5.6% for non-ETP-ALL (P=0.003). The overall survival rates were 13.3%±11.0% for ETP-ALL and 64.7%±6.3% for non-ETP-ALL (P=0.002). Our findings demonstrate that early T-cell precursor leukemia is a very high-risk subtype of acute lymphoblastic leukemia with poor prognosis.

关键词： acute lymphoblastic leukemia     early T precursor     prognosis    

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Simulation analysis of environmental risk accident and management of high-sulfur gas field development

WANG Xiao, HAO Fanghua, ZHANG Xuan, SUN Wen, CHENG Hongguang

《环境科学与工程前沿（英文）》 2008年 第2卷 第3期   页码 318-325 doi: 10.1007/s11783-008-0033-9

摘要： Environmental risk of high sulfur gas field exploitation has become one of the hot spots of environmental management studies. Severe gas HS blowout accidents in recent years have shown that poor understanding and estimates of the poisonous gas movement could lead to dangerous evacuation delays. It is important to evaluate the real concentration of HS, especially in complex terrain. Traditional experiential models are not valid in the case of rough terrain, especially in low-lying areas where the gas accumulates. This study, using high sulfur content gas field of Sichuan “Pu Guang gas field” as study object and adopting objective diagnosis of wind field of land following coordinate three dimensions, applied Lagrangian Puff Model and breaking up technique of puffs to simulate the HS diffusion condition of blowout accidents produced in the high sulfur content gas field of complex terrain area. The results showed that the HS distribution did not occur mainly in low wind direction, and due to the obstruction of the mountain’s body, it accumulated in front of mountain on produced turn over, flowed around submitted jumping type distribution. The mountain waist near the hilltop and low hollow river valley site rapture points simulating contrast showed that the higher the rapture point, the better the diffusing condition of pollutant, the distribution of risk sensitive point decided piping rupture environmental risk size combining the HS diffusion result and residential area dispersing in the study area, synthetic judge located in the high rapture point environmental risk was smaller than the low hollow point, thus it was suggested to carryout laying of lining build of equal high line of higher terrain. According to simulation results, the environmental risk management measures aimed at putting down adverse effects were worked out.

关键词： mountain ’     rapture     Lagrangian     hollow     produced    

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Venetoclax and low-dose cytarabine induced complete remission in a patient with high-risk acute myeloid

Bingshan Liu, Roshni Narurkar, Madhura Hanmantgad, Wahib Zafar, Yongping Song, Delong Liu

《医学前沿（英文）》 2018年 第12卷 第5期   页码 593-599 doi: 10.1007/s11684-018-0635-y

摘要：

Conventional combination therapies have not resulted in considerable progress in the treatment of acute myeloid leukemia (AML). Elderly patients with AML and poor risk factors have grave prognosis. Midostaurin has been recently approved for the treatment of FLT-3-mutated AML. Venetoclax, a BCL-2 inhibitor, has been approved for the treatment of relapsed and/or refractory chronic lymphoid leukemia. Clinical trials on applying venetoclax in combination with cytarabine and other agents to treat various hematological malignancies are currently underway. Here, we present a case of a male patient with poor performance status and who developed AML following allogeneic hematopoietic stem cell transplant for high-risk myelodysplasia. The patient with high risk AML achieved complete response to the combined treatment regimen of low-dose cytarabine and venetoclax. Furthermore, we reviewed current clinical trials on the use of venetoclax for hematological malignancies.

关键词： venetoclax     cytarabine     AML     leukemia    

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Integrated risk assessment framework for transformation products of emerging contaminants: what we know

《环境科学与工程前沿（英文）》 2023年 第17卷 第7期 doi: 10.1007/s11783-023-1691-3

摘要：

● A better risk assessment can combine the improved non-target analysis method.

关键词： Risk assessment frameworks     Transformation products     Emerging contaminants     High-throughput toxicity screening     Water treatment    

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Occurrence and distribution of micro- and mesoplastics in the high-latitude nature reserve, northern

《环境科学与工程前沿（英文）》 2022年 第16卷 第9期 doi: 10.1007/s11783-022-1534-7

摘要：

• The first study on micro(meso)plastics (MMPs) in the Liaohe River Reserve is reported.

关键词： Microplastics     Mesoplastics     Water     Sediment     Characteristic     Risk Assessment    

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Properties of cement grout modified with ultra-fine slag

Sowmini GOPINATHAN, K B ANAND

《结构与土木工程前沿（英文）》 2018年 第12卷 第1期   页码 58-66 doi: 10.1007/s11709-017-0383-0

摘要： The purpose of the study is to obtain a cement grout with improved performance. The grout mixes of the present study contain cement, ultra-fine slag (UFS), super plasticizer and water. Properties like flowability, bleeding, compressive strength and shrinkage of cement grouts have been studied. Rheological parameters were also studied in order to explain the grout workability. The results show that, cement replacement with slag in grouts could reduce bleeding substantially without affecting the workability of the mixes. Introduction of slag enhanced the compressive strength and reduced shrinkage reasonably. Ultra-fine slag can be used as a supplementary cementitious material in cementitious grouts in order to improve the grout behavior.

关键词： cement grout     ultra-fine slag     flowability     bleeding     viscosity    

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High risk factors for pulmonary fungous infection in intensive care units of neurosurgery

ZHU Wenyu, TAN Liping, CHEN Xiangfeng, HUANG Qiang, LAN Qing

《医学前沿（英文）》 2007年 第1卷 第3期   页码 299-303 doi: 10.1007/s11684-007-0057-8

摘要： By analyzing the high risk factors for pulmonary fungous infection in intensive care units of neurosurgery, the strategy of early diagnosis and treatment was explored. According to the domestic diagnostic standard on pulmonary fungous infection, clinical data on 58 patients with the infection in our department were analyzed. One hundred and seventeen strains of fungi were separated from the 58 cases. Candidiasis was the most frequent type, accounting for 92.3% of the cases. Conditions such as the severity of primary diseases, long-time coma, long-term use of broad-spectrum antibiotic, abuse of glucocorticoid, the open airway, and some invasive intubations, may be regarded as high risk factors for pulmonary fungous infection. Fluconazole showed good clinical effects on the treatment of fungous infection. To eliminate these high risk factors, early diagnosis and the use of prophylactic antifungal agents can help reduce the incidence of pulmonary fungous infection.

关键词： seventeen     incidence     glucocorticoid     broad-spectrum antibiotic     Candidiasis    

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High cadmium pollution risk on vegetable amaranth and a selection for pollution-safe cultivars to lowerthe risk

Yihui ZHOU, Meng XUE, Zhongyi YANG, Yulian GONG, Jiangang YUAN, Chunyan ZHOU, Baifei HUANG

《环境科学与工程前沿（英文）》 2013年 第7卷 第2期   页码 219-230 doi: 10.1007/s11783-012-0469-9

摘要： A pot experiment was carried out by growing 29 different genotypes ( spp.) of vegetable amaranth under low- (0.12 mg·kg ) and middle- (0.40 mg·kg ) cadmium (Cd) exposure. The result showed that amaranth was vulnerable to cadmium (Cd) contamination in soil. Variations of Cd concentrations in both roots and edible parts among genotypes were significant ( <0.001) in both treatments. Cd concentrations in edible parts of the tested genotypes grown under low- and middle-Cd levels were significantly correlated ( <0.01), implying that Cd-accumulating property of amaranth is genotype-dependent. Differences in Cd chemical forms between cv. Nanxingdayemashixian (cv. Nan), a selected typical pollution-safe cultivar (Cd-PSC), and cv. Pennongjianyexian (cv. Pen), a selected typical non-Cd-PSC, under different Cd exposure conditions were compared. It was found that the alternation of Cd in F (Cd form extracted by 1 mol·L NaCl) may be a key factor in regulating Cd accumulation of different amaranth genotypes and that the protein-binding Cd is considered to be associated with Cd translocation. The results indicated that amaranth is capable of enduring high level of Cd pollution when grown as vegetable crop, and accordingly, consuming vegetable amaranth would bring high health risk. Therefore, adopting Cd-PSC strategy would help reducing the risk of Cd pollution in amaranth. In this study, cv. Nan was identified as a Cd-PSC and recommended to be applied production practice.

关键词： Amaranth     Cadmium (Cd)     Cd accumulation     pollution-safe cultivar (PSC)     Cd chemical forms     health risk    

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Minimal residual disease-directed immunotherapy for high-risk myelodysplastic syndrome after allogeneic

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

《医学前沿（英文）》 2019年 第13卷 第3期   页码 354-364 doi: 10.1007/s11684-018-0665-5

摘要： The efficacy of minimal residual disease (MRD)-directed immunotherapy, including interferon- (IFN- ) treatment and chemotherapy plus granulocyte colony-stimulating factor-primed donor leukocyte infusion (chemo-DLI), was investigated in patients with high-risk myelodysplastic syndrome (MDS) who were MRD-positive after allogeneic hematopoietic stem cell transplantation (allo-HSCT). High-risk MDS patients who received non-T-cell-depleted allo-HSCT at the Peking University Institute of Hematology and were MRD-positive after allo-HSCT were studied ( =47). The MRD-positive status was considered if leukemia-associated aberrant immune phenotypes or Wilms’ tumor gene 1 expression is present in a single bone marrow sample. The cumulative incidence of the relapse and non-relapse mortality 2 years after immunotherapy were 14.5% and 21.4% ( =0.377) and 9.1% and 0.0% ( =0.985) for patients in the IFN- and chemo-DLI groups, respectively. The probability of disease-free and overall survival 2 years after immunotherapy were 76.4% and 78.6% ( =0.891) and 84.3% and 84.6% ( =0.972) for patients in the IFN- and chemo-DLI groups, respectively. Persistent MRD after immunotherapy was associated with poor survival. Thus, the MRD-directed immunotherapy was effective for patients with high-risk MDS who were MRD-positive after allo-HSCT, and the efficacy was comparable between chemo-DLI and IFN- treatment.

关键词： donor leukocyte infusion     hematopoietic stem cell transplantation     interferon-   

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Partial portacaval shunt with H-grafts to treat portal hypertension

XU Geliang, HU Hejie, LI Jiansheng, YANG Shugao, CHAI Zhongpei, XU Rongnan

《医学前沿（英文）》 2007年 第1卷 第3期   页码 279-281 doi: 10.1007/s11684-007-0053-z

摘要： Partial portosystemic shunts have been popularized because of a reported low rate of mortality and morbidity (especially encephalopathy, liver failure and occlusion). The results of partial portacaval shunts [small-diameter expanded polytetrafluoroethylene (ePTFE) H-graft portacaval shunt] were retrospectively reviewed to evaluate the clinical efficacy in the treatment of portal hypertension. Forty-three patients with portal hypertension were treated by small-diameter H-graft of ePTFE portacaval shunt from May 1995 to April 2006. Thirty-three had externally ringed grafts and ten had non-ringed ones. Ten had grafts of 10 mm in diameter and 33 had grafts of 8 mm. The left gastric artery and coronary vein were ligated in all the cases. Six had pericardial devascularization and splenectomy was performed in 42. An average decrease of free portal pressure (FPP) from (33.24 ± 4.78) cmHO before shunting and (13.65 ± 5.65) cmHO after shunting was observed. The portal blood flow was reduced by one-third of that before shunt. Thirty-eight patients survived and no upper gastro-intestinal rebleeding occurred in the follow-up period (50.5 months in average). Two were out of contact. Color Doppler ultrasonography and/or portography revealed the shunts were patent in 38 cases and were occluded in three cases (3/41, 7.3%). Encephalopathy developed in five cases (5/41, 12.2%). Partial (small-diameter ePTFE H-graft) portacaval shunting can reduce the portal pressure effectively. Majority of the hepatic flow from the portal vein can be maintained adequately. The shunts with reinforced grafts can keep a higher rate of patency. The morbidity of encephalopathy was lower than those with total shunt. The partial portacaval shunt is effective in preventing recurrent variceal bleeding.

关键词： diameter     clinical efficacy     bleeding     pericardial devascularization     Forty-three    

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标题 作者 时间 类型 操作

Drug-coated balloon-only strategy for percutaneous coronary intervention of left main coronary artery disease: the importance of proper lesion preparation

期刊论文

Analysis of the treatment outcomes of esophageal variceal bleeding patients from multiple centers in

WANG Zhiqiang

期刊论文

Identification of surgical patients at high risk of OSAS using the Berlin Questionnaire to detect potentialhigh risk of adverse respiratory events in post anesthesia care unit

null

期刊论文

Effects of microfine aggregate in manufactured sand on bleeding and plastic shrinkage cracking of concrete

Branavan ARULMOLY; Chaminda KONTHESINGHA; Anura NANAYAKKARA

期刊论文

Status of hyperhomocysteinemia in China: results from the China Stroke High-risk Population Screening

期刊论文

Early T-cell precursor leukemia: a subtype of high risk childhood acute lymphoblastic leukemia

null

期刊论文

Simulation analysis of environmental risk accident and management of high-sulfur gas field development

WANG Xiao, HAO Fanghua, ZHANG Xuan, SUN Wen, CHENG Hongguang

期刊论文

Venetoclax and low-dose cytarabine induced complete remission in a patient with high-risk acute myeloid

Bingshan Liu, Roshni Narurkar, Madhura Hanmantgad, Wahib Zafar, Yongping Song, Delong Liu

期刊论文

Integrated risk assessment framework for transformation products of emerging contaminants: what we know

期刊论文

Occurrence and distribution of micro- and mesoplastics in the high-latitude nature reserve, northern

期刊论文

Properties of cement grout modified with ultra-fine slag

Sowmini GOPINATHAN, K B ANAND

期刊论文

High risk factors for pulmonary fungous infection in intensive care units of neurosurgery

ZHU Wenyu, TAN Liping, CHEN Xiangfeng, HUANG Qiang, LAN Qing

期刊论文

High cadmium pollution risk on vegetable amaranth and a selection for pollution-safe cultivars to lowerthe risk

Yihui ZHOU, Meng XUE, Zhongyi YANG, Yulian GONG, Jiangang YUAN, Chunyan ZHOU, Baifei HUANG

期刊论文

Minimal residual disease-directed immunotherapy for high-risk myelodysplastic syndrome after allogeneic

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

期刊论文

Partial portacaval shunt with H-grafts to treat portal hypertension

XU Geliang, HU Hejie, LI Jiansheng, YANG Shugao, CHAI Zhongpei, XU Rongnan

期刊论文